The connection between the gut and brain, often referred to as the gut-brain axis, highlights the gut’s role as a “second brain” due to its numerous neurons that communicate with the brain. Gut bacteria, or microbes, significantly influence nutrient absorption and usage, with over a trillion microbes inhabiting a healthy gut. This connection impacts anxiety, depression, hunger, satiety, and cravings, which are crucial factors in substance use recovery. Understanding how substance use affects the gut and how proper nutrition supports gut health is essential for effective recovery and overall well-being.